Cardiovascular Disease | cardiomaths.net

The body’s ability to form blood clots is its natural defence against bleeding but blood clots formed inappropriately (thrombus) can block blood flow and therefore lead to heart attacks and strokes. A clot is principally formed from two components, small anuclear cells (platelets) and fibrin monomers.

Platelet Activation

In the ICMR at the University of Reading we are producing mathematical models of platelet activation – The VirtualPlatelet. An online app that allows you to run simulations of the above models is available here. This work is funded by

Dunster et al. (2015). Regulation of early steps of GPVI signal transduction by phosphatases: a systems biology approach. PLoS Comput Biol, 11(11), p.e1004589.

Mazet et al. (2015). A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications. Scientific reports, 5

Coagulation Cascade

In collaboration with researchers from the Department of Cardiovascular Sciences at the University of Leicester, the Leicester Cardiovascular Biomedical Research Unit and Moscow State University we are analysing and utilising mathematical models of the coagulation cascade (that leads to the formation of fibrin monomers).

Dunster, J.L. and King, J.R., (2016). Mathematical modelling of thrombin generation: asymptotic analysis and pathway characterization. IMA Journal of Applied Mathematics, p.hxw007.

A.V. Belyaev et al. (2018). Modelling thrombosis in silico: frontiers, challenges, unresolved problems and milestones. Physics of life reviews, p.hxw007.